منابع مشابه
Studies on Renal Juxtaglomerular Cells
Accumulation of granules in the juxtaglomerular cells occurred in rats which were maintained for 5 to 6 weeks on a diet low in sodium, chloride. Cytological evidence suggests that this was probably a storage phase of secretion following a decrease in the rate of liberation of the granules. Administration of DCA (desoxycorticosterone acetate) to salt-deficient rats did not alter this appearance ...
متن کاملSTUDIES ON RENAL JUXTAGLOMERULAR CELLS IlL THE EFFECTS OF EXPERIMENTAL RENAL DISEASE AND HYPERTENSION
Following Ruyter's discovery of juxtaglomerular cells (1), Goormaghtigh's investigations led him to implicate these cells in the etiology of hypertension. In renal ischemia, whether in man or experimental animals, he observed hyperplasia and hypergranulation of juxtaglomerular cells. He believed that these changes preceded and might have been responsible for hypertension resulting from renal is...
متن کاملJuxtaglomerular cells.
• Because juxtaglomerular (JG) cells are sprinkled throughout the renal cortex, just as beta cells are sprinkled throughout the exocrine pancreas, the classical extirpation and substitution approach in endocrinology is a limited means for the study of their function. Until they can be isolated and pure extracts made, or until an "alloxan" for JG cells is discovered, their study will depend chie...
متن کاملRenal Failure in Mice with Gs Deletion in Juxtaglomerular Cells
Background: Mice with deletion of Gs in renin-producing cells (RC/FF mice) have been shown to have greatly reduced renin production and lack of responsiveness of renin secretion to acute stimuli. In addition, young RC/FF mice are hypotensive and have a vasopressin-resistant concentrating defect. In the present study we have determined the longterm effect on renal function, blood pressure, and r...
متن کاملLiberators of NO exert a dual effect on renin secretion from isolated mouse renal juxtaglomerular cells.
This study aimed to examine the role of nitric oxide (NO) in the regulation of renin secretion from renal juxtaglomerular (JG) cells. Using primary cultures of mouse renal JG cells, we found that sodium nitroprusside (SNP) and 3-morpholino-sydnonimin-hydrochloride (SIN-1), two structurally different liberators of NO, led to a transient inhibition during the first hour followed by a marked dose-...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1955
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.102.2.205